血清AFP-L3在老年人肝癌双介入治疗中的临床研究

李新丰*   黄天从  刘德鑫   王高雄   苏永利

【摘要】目的 研究AFP-L3、GP73及AFP在肝动脉化疗栓塞（TACE）联合射频消融（RFA）治疗老年人肝癌（PHC）前后血清水平的变化。方法 42例PHC老年患者治疗前均接受肝穿刺病理证实，在TACE联合RFA（双介入）治疗前后检测血清AFP、GP73 及AFP-L3的水平变化情况；结果 42例患者经双介入治疗前后AFP、GP73及 AFP-L3水平进一步下降，差异均有统计学意义（P ＜ 0.01）。而其中双介入的30例与RFA前比较，AFP-L3下降具有统计学意义（P ＜ 0.05）。结论 老年PHC经双介入治疗后三种指标进一步下降，而血清AFP-L3下降与肿瘤的毁损程度呈正相关。

【关键词】 原发性肝癌；AFP-L3；GP73；AFP

          Clinical research of serum AFP-L3 in the treatment of elderly patients with hepatocellular carcinoma with TACE and RFA.Li Xinfeng,Huang Tiancong,Liu Dexin,et al.The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000,Fujian，China

【Abstract】  Objective  To study the changes of serum level of AFP-L3, GP73 and AFP before and after transcatheter arterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) in the treatment of elderly patients with hepatocellular carcinoma (PHC). Methods  42 cases of elderly PHC patients diagnosed by liver puncture were selected and detection of the serum AFP, GP73, AFP - L3 level changes have been detected during RFA (double interventional therapy) with TACE before and after treatment. Results The level of AFP-L3 AFP and GP73 of 42 patients decreased further before and after interventional therapy, the differences were statistically significant (P < 0.01). In 30 cases with double intervention, the decrease of AFP-L3 was statistically significant compared with that before RFA (P < 0.05).  Conclusions The three indexes of the elderly patients with PHC were further decreased after double intervention, and the decrease of serum AFP-L3 was positively correlated with the degree of tumor damage.

【Key words】  Primary hepatic carcinoma；AFP-L3；AFP；GP73