氨溴特罗口服液联合酮替芬与小剂量氨茶碱治疗咳嗽变异性哮喘56例
吴启富* 滕朝霞
【摘要】目的 观察氨溴特罗口服液联合酮替芬与小剂量氨茶碱治疗咳嗽变异性哮喘的临床效果。方法 选择120例咳嗽变异性哮喘随机分为治疗组（60例）和对照组（60例）。两组均给予酮替芬与氨茶碱，治疗组加用氨溴特罗口服液，对照组加用舒喘灵，疗程2～6w。结果 治疗组脱落4例，对照组脱落6例。治疗2w和4w后，两组临床症状改善情况比较差异有统计学意义（P＜0.05）；随访6个月复发率治疗组7.14%，对照组22.22%（P＜0.05）；均未发现不良反应。结论 氨溴特罗口服液联合酮替芬与小剂量氨茶碱治疗咳嗽变异性哮喘疗效显著，快速安全，具有较高的临床应用价值。
【关键词】咳嗽变异性哮喘；氨溴特罗口服液；酮替芬；氨茶碱；舒喘灵
Clinical Observation of Treatment by Ambroxol and Clenbuterol Oral Solutions Combined Low Dose Aminophylline in 56 Cases of Cough Variant Asthma, Wu Qifu, Teng Zhaoxia. The Material and Children Health Hospital, Huaying ,Sichuan 638600,China
【Abstract】 Objective To study the clinical effect of treatment by ambroxol and clenbuterol oral solutions combined low dose aminophylline for cough variant asthma. Methods 120 patients with cough variant asthma were divided into treatment group (60 cases) and control group (60 cases).Both groups were treated with ketotifen and low dose aminophylline, the treatment group used ambroxol and clenbuterol oral solutions and salbutamol was used in control group, for 2 to 6 weeks. Result Except 4 patients in the treatment group and 6 in the control group vain, after treatment of 2 weeks and 4 weeks, the differences of improvement in two groups had statistically significance (P<0.05).Follow-up after 6 months, recurrence rate of the treatment group was 7.14%, and the control group was 22.22%,P<0.05.There was no adverse effect observed in two groups. Conclusion Treatment by ambroxol and clenbuterol oral solutions combined low dose aminophylline for cough variant asthma is effective, fast and safe, with high clinical application values.
【Key words】Cough variant asthma; Ambroxol and clenbuterol oral solutions; Ketotifen ; Aminophylline; Salbutamol