GDF-15治疗对肝癌化疗敏感性影响的分析
谢琼 易宏锋*
【摘要】目的 探讨GDF-15(生长分化因子-15）治疗对于肝癌化疗敏感性的影响。方法 通过采用免疫组织化学方法SP分别检测行GDF-15治疗与未行GDF-15治疗的肝癌组织中丝氨酸/苏氨酸蛋白激酶受体(RSK)及多药耐药相关蛋白（MRPI）的表达情况，从而探讨GDF-15对于肝癌化疗敏感性的影响。结果 在20例行GDF-15治疗组，其丝氨酸/苏氨酸蛋白激酶受体(RSK)表达强度为：0.4358±0.01246，15例未行GDF-15治疗组，其丝氨酸/苏氨酸蛋白激酶受体(RSK)表达强度为：0.3012±0.01278，前者表达强度明显高于后者（P＜0.05），因此GDF-15治疗组，其疗效好于非GDF-15治疗组；在20例行GDF-15治疗组，其多药耐药相关蛋白（MRPI）表达强度为：0.3574±0.02159，15例未行GDF-15治疗组，其多药耐药相关蛋白（MRPI）表达强度为：0.3101±0.01108，前者表达强度明显高于后者（P＜0.05），因此GDF-15治疗组，其可增加肝癌对药物的耐药性。结论 在行肝癌化疗时，家用GDF-15的治疗可增强机体抗肿瘤免疫，但是另一外面可以增加肝癌对化疗药物的耐药性，减低其敏感性，因此，对于肝癌的化疗，加用GDF-15的治疗可降低其效果。
【关键词】 肝癌；GDF-15；丝氨酸/苏氨酸蛋白激酶受体；多药耐药相关蛋白
Analysis of GDF—15 treatment for the sensitivity of liver cancer chemotherapy, Xie Qiong，Yi Hongfeng， Tianmen NO.2 People’s Hospital, Tianmen, Hubei 431700, China
【Abstract】 Objective To investigate the effecacy of GDF—15 treatment for liver cancer chemosensitivity. Methods Immunohistochemical SP was used to detect expressions of Serine/threonine protein kinase receptor (RSK) and multi-resistant protein (MRPI) in liver cancer of two groups, one was using GDF-15 treatment and the other was not, explored the effect of GDF 15-for chemosensitivity of liver cancer. Results In 20 cases with GDF-15 treatment, its serine/threonine protein kinase receptor (RSK) expression intensity was 0.4358±0.01246,while in 15 cases without GDF-15, the serine/threonine protein kinase receptor (RSK) expression intensity was 0.3012±0.01278. The former expression intensity was significantly higher than the other(P<0.05), and therefore the efficacy of group with GDF-15 was better than the group without GDF-15.In 20 cases with GDF—15, the multidrug resistance-associated protein (MRPI) expression intensity was 0.3574±0.02159,while in 15 cases without GDF—15, the multidrug resistance—associated protein (MRPI) expression intensity was 0.3101±0.01108. The former expression level was significantly higher than the other (P <0.05). Therefore the treatment group GDF-15 had higher liver cancer drug resistance. Conclusion HCC line chemotherapy, home GDF—15 treatment can enhance the body's anti—tumor immunity, but on the other side it can increase liver resistance to chemotherapeutic drugs, and reduce their sensitivity. Therefore, for liver cancer chemotherapy, using GDF—15 treatment can reduce its effectiveness.
【Key words】 Liver cancer; GDF—15; Serine/threonine protein kinase receptor; Multidrug resistance—associated protein